Macromolecular transport within heart valves.
نویسندگان
چکیده
منابع مشابه
Macromolecular transport within heart valves.
The present study documents the permeability characteristics of heart valvular endothelium to low-density lipoprotein (LDL), albumin, and horseradish peroxidase (HRP). Using quantitative autoradiography, LDL and albumin concentrations were measured within aortic valves of squirrel monkeys and rabbits after 30 minutes of in vivo circulation. The valvular concentration profiles were analyzed usin...
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This paper proposes a new, two-dimensional convection-diffusion model for macromolecular transport in heart valves based on horseradish peroxidase (HRP) experiments on rats presented in the first of the papers in this series (Part I; Zeng Z, Yin Y, Huang AL, Jan KM, Rumschitzki DS. Am J Physiol Heart Circ Physiol 292: H2664-H2670, 2007). Experiments require two valvular intimae, one underneath ...
متن کاملMacromolecular transport in heart valves. I. Studies of rat valves with horseradish peroxidase.
The present study aims to experimentally elucidate subtle structural features of the rat valve leaflet and the related nature of macromolecular transport across its endothelium and in its subendothelial space, information necessary to construct a rational theoretical model that can explain observation. After intravenous injection of horseradish peroxidase (HRP), we perfusion-fixed the aortic va...
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Macromolecule transport within an artery is investigated and a comprehensive analytical solution is presented. The transport within the lumen and the arterial wall are coupled. Arterial wall is modeled as a four-layer porous wall. The layers are all treated as macroscopically homogeneous porous media. The volume-averaged porous media equations are employed to solve for transport through the por...
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Electron microscopy has already given much information about the macromolecular components of striated muscle (1, 4). Thus it is shown that myofibrils of teased muscle are ribbons composed of parallel arrays of filaments associated with an amount of seemingly amorphous material that is great,est in the anisotropic regions. For the present work, strips of psoas muscle separated from a rabbit at ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1989
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.64.6.1213